IPAC-RS

Cascade Impaction (CI)

Our overarching goal is to determine and publicize best scientific approaches for aerodynamic particle size distribution (APSD) measurements (such as by cascade impaction) in the context of characterization, change and control of OINDP.

Currently, we are completing an experiment to further study the ability of efficient data analysis (EDA) to detect changes in APSD of a metered dose inhaler (MDI). The experiment is being conducted in parallel in three different laboratories.
A subgroup of CI WG is also developing best practices for abbreviated impactor measurement (AIM) testing of dry powder inhalers (DPIs).

Click here to view the Cascade Impaction Tutorial Modules.

News

Cascade Impaction Poster (January 2016 Update)

The Cascade Impaction Working Group poster abstract focused on AIM’s calibration traceability chains has been accepted by RDD 2016. Look for the poster and working group members at RDD in Arizona!

Cascade Impaction Update (November 2015)

The Cascade Impaction Working Group has completed a manuscript comparing Efficient Data Analysis and the Fine Particle Dose metric for controlling aerodynamic particle size distribution. The manuscript has been provided to the Board of Directors for review and approval.  When finalized, the paper will be submitted to the AAPS PharmSciTech journal.

Cascade Impaction AIM/EDA Workshop

The AIM/EDA workshop at RDD Europe was very well attended and well received. Slides and Q&As are now posted on the event page.

Cascade Impaction

The IPAC-RS Cascade Impaction working group has approved and expressed support for the translation of its book, Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products, into Chinese, as well as the organization of a conference or workshop session addressing Cascade Impaction testing in China. The working group will collaborate with the GRRO China team on these efforts.

IPAC-RS RDD 2014 Presentations

At RDD 2014 in Puerto Rico, four IPAC-RS members representing GRRO China, the Device Working Group, and the Cascade Impaction Working Group gave very well-received presentations.

Past Events

Publications

Equivalence Considerations for Orally Inhaled Products for Local Action

is available at: IPAC-RS. By Working Group: Cascade Impaction (CI). By Working Group: Device. Carole Evans, David Cipolla, Tim Chesworth, Eva Agurell, Richard Ahrens, Dale Conner, Sanjeeva Dissanayake, Myrna Dolovich, William Doub, Anders Fuglsang, Afredo García Arieta, Michael Golden, Robert Hermann, Günther Hochhaus, Susan Holmes, Paul Lafferty, Svetlana Lyapustina, Parameswaran Nair, Dennis O'Connor, David Parkins, Ilse Peterson, Colin Reisner, Dennis Sandell, Gur Jai Pal Singh, Marjolein Weda, and Patricia Watson Journal of Aerosol Medicine and Pulmonary Drug Delivery, Vol. 25, No. 3: 117-139 (published)

Generalized Simplified Approaches For MMAD Determination

By Working Group: Cascade Impaction (CI). David Christopher, Monisha Dey, Lana Lyapustina, Jolyon Mitchell, Terrence Tougas, Mike Van Oort, Helen Strickland, Bruce Wyka USP Pharmacopeial Forum, 36(3), pp 812-823 (published)

Presentations

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